Exosome Therapy: Drinking the Kool-Aid or the Real Deal?

Exosome therapies are attempting  to muscle out  classic stem cell therapies and  make them  less relevant. Mesenchymal Stem Cells obtained through C-section produced donations, release exosomes to enact their healing capabilities. Exosomes are lipid vesicles that contain: proteins, growth factors, lipids, and microRNA (the blueprint for proteins) amongst other things. Exosomes can be reliably counted and undergo a quality analysis . There is plenty of debate amongst vendors as to which one is the secret sauce.

Qualitative analysis, has shown that the growth factors and microRNA contained in the exosomes  trigger both repair and growth. As a natural paracrine signaling molecule, they respond to and hone in on damaged cells nearby that are releasing chemotaxic agents (chemical signals purposed to draw in the right exosomes). The exosomes do not need to be “smart,” your body does the work to direct them exactly where they are needed through chemotaxis. They are an acellular, natural signaling molecule which means your body cannot reject or have an immune response against them. Additionally, as they are not “living cells,” they do not rely on viability (staying alive) as is an absolute necessity with classic stem cell therapies. They are small enough that they can be sterile filtered to ensure no bacterial contamination, something that you cannot achieve with stem cell products due to their large size. Exosome therapy provides an alternate to more expensive stem cell therapies. As new studies are published there will be more data to  weigh along with the the anecdotal evidence

Regenerativemedicine copy